Welcome to the Gilkes Lab

Breast & Gynecologic Malignancies Group   Johns Hopkins School of Medicine

About the Gilkes Lab

The Gilkes Lab studies how tumor hypoxia reshapes cell state, extracellular matrix, and metastatic potential. We combine mechanistic biology with clinically relevant models to understand—and ultimately disrupt—metastatic progression.

Below are snapshots across the years showing how our team and lab culture have evolved. Click any image to view it larger.

Gilkes Lab early years Early years
Gilkes Lab 2023 2023
Gilkes Lab 2019 2019
Gilkes Lab 2021 2021
Gilkes Lab 2022 2022
Gilkes Lab Halloween Culture
Natalie and Daniele Gilkes Mentorship
Daniele Gilkes Leadership

News and More!

Research

ITGA5

Novel hypoxia-inducible genes

Using RNA sequencing of over 30 breast cancer cell lines, we developed a prognostic hypoxia gene signature that includes novel hypoxia-induced genes. We want to know these novel genes function in breast cancer?

ECM

Novel Imaging Techniques

Using imaging techniques like Light Sheet Microscopy we study brain metastasis. This is an image of an entire mouse brain (blue) with a growing metastatic lesion (green).

Metastasis

Hypoxia and Metastasis

We've developed a hypoxia color changing system to help us determine hypoxia's role in metastasis in vivo. Above are organoids and spheroids that were developed from this model.

People

Daniele Gilkes, PhD

Principal Investigator
View Bio

Daniele M. Gilkes is an Assistant Professor in the Oncology Department, under the Breast and Ovarian Cancer Program, at Johns Hopkins School of Medicine. She earned B.S.ChE and M.S. degrees in the University of Florida. After completing her PhD in Cancer Biology at the University of South Florida, Daniele became a Susan G. Komen Postdoctoral Fellow in the lab of Gregg Semenza, MD, PhD at Johns Hopkins School of Medicine. Later, she became a Research Assistant Professor in the lab of Denis Wirtz, PhD in the Chemical & Biomolecular Engineering Department at Johns Hopkins University. Daniele opened her lab in 2015, and now focuses on studying the role of the tumor microenvironment, primarily hypoxia and the extracellular matrix, in breast cancer.

Maybe you?

Postdoctoral Fellow

Open Position
We currently have an open postdoctoral fellowship position in the lab. Interested candidates are encouraged to reach out — maybe this could be you.
Coming soon

Kay Kang

Master’s Degree Student
Master’s degree student at Johns Hopkins University.
Coming soon

Wenrui Hu

Master’s Degree Student
Master’s degree student at Johns Hopkins University.
Coming soon

Vini Jain Vikas

Master’s Degree Student
Master’s degree student at Johns Hopkins University.
Coming soon

Leqi Shen

Undergraduate Student
Undergraduate student in the Department of Molecular and Cell Biology at Johns Hopkins University.
Coming soon

Annanya Sharma

Undergraduate Student
Undergraduate student in the Department of Molecular and Cell Biology at Johns Hopkins University.
Coming soon

Yashasri Gouda

Undergraduate Student
Undergraduate student in the Department of Molecular and Cell Biology at Johns Hopkins University.

Click here to see a list of our former members and what they're up to now!

Feel free to contact us

General Inquiry: gilkeslab@gmail.com

Direct Correspondence: dgilkes1@jhu.edu

Twitter: @GilkesLab

Breast and Gynecologic Malignancies Program

1650 Orleans Street

CRBI Room 128

Baltimore MD, 21231

Funding

If you are interested in supporting our lab's research, gifts are accepted here.